Article: An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.
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Wemhöner K; Kanyshkova T; Silbernagel N; Fernandez-Orth J; Bittner S; Kiper AK; Rinné S; Netter MF; Meuth SG; Budde T; Decher N
Front Mol Neurosci, 2015
Studies of Ih and HCN channels in thalamocortical relay neurons of rat (WAG/Rij; GAERS) and mouse (HCN2-/- knock-out) models of Absence epilepsy.
| Reference |
Animal |
Tissue |
Expression
|
Ih
|
|
HCN1 |
HCN2 |
HCN3 |
HCN4 |
V1/2 |
Amplitude |
cAMP sensitivity |
τ act |
| Kanyshkova et al., 2012 |
WAG/Rij versus ACI |
TC relay neurons (dLGN, P90; VB, P30) |
↑ Prot. (dLGN) / = Prot. (VB) |
const. |
(↑) Prot. on P7 |
const. |
-7.9 mV (dLGN) -3 mV (VB) |
↑ ~1.5-fold (dLGN) |
Reduced |
Faster |
| Budde et al., 2005 |
WAG/Rij versus ACI |
TC relay (dLGN, P16–29) |
↑ mRNA and Prot. (dLGN) |
const. |
const. |
const. |
-5.2 mV (dLGN) -2.8 mV (VB) |
Not analyzed systematically |
Reduced |
Faster |
| Strauss et al., 2004 |
WAG/Rij versus ACI and Wistar |
Pyramidal (layers 2–3) somatosensory cortex |
ccc Prot.∗ / = mRNA |
const. |
const. |
const. |
+9 mV (somatic) |
↓ ~0.5-fold (somatic) |
n.t. |
Slower |
| Kole et al., 2007 |
WAG/Rij versus Wistar |
Pyramidal (layer 5) somatosensory cortex |
↓ Prot. (68%) |
const. |
n.t. |
n.t. |
const. (dendritic) |
↓ ~0.5-fold (dendritic) |
n.t. |
n.t. |
| Ludwig et al., 2003 |
HCN2-/- mouse |
TC relay neurons and hippocampus |
const. |
-/- |
const. |
const. |
-27 mV (TC) -2 mV (CA) |
↓ 80% (TC)↓ 39% (CA) |
Reduced |
n.t. |
| Cain et al., 2014 |
GAERS versus NEC |
TC relay neurons (VB, P7–P150) |
↑ Prot. (VB) |
const. |
↑ Prot. (VB) |
const. |
const. |
↑ ~2-fold |
n.t. |
n.t. |
| Kuisle et al., 2006 |
GAERS versus NEC |
TC relay neurons (VB, 19–24 days, 3–8 months) |
↑ mRNA (VB, NRT) |
const. |
n.t. |
const. |
const. |
const. |
Reduced |
n.t. |
CA pyramidal neurons of the hippocampus; const. = constant; dLGN = dorsal lateral geniculate nucleus; GAERS = Genetic Absence Epilepsy in Rats from Strasbourg; NEC = non-epileptic controls; NRT = Nucleus reticularis thalami; n.t. = not tested; Prot. = Protein; TC = thalamocortical; VB = ventrobasal thalamic complex; ‘↑’ = up-regulated; ‘↓’ = down-regulation; ‘ = ’ = not regulated. ∗hippocampus ↓46%, neocortex ↓21%, cerebellum ↓57%.
Inferred neuron-electrophysiology data values
| Neuron Type |
Neuron Description |
Ephys Prop |
Extracted Value |
Standardized Value |
Content Source |
